Microbiota Community of Irritable Bowel Syndrome in Episodes and Remission Phase

Shandong University30 enrolled

Overview

Analyze microbiota community of irritable bowel syndrome in episodes phase and remission phase.

The pathophysiology of IBS is incompletely understood, it may involve an altered intestinal microbiota. Since the microflora composition of IBS is various in different studies, The investigators plan to compare the intestinal microbiota of IBS patients in episodes phase and remission phase with healthy controls,trying to find the difference.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Irritable Bowel Syndrome

Interventions

collect faeces from participantsOTHER

analyze the fecal microbiota community using 16S rDNA detection technique

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * the presence of Rome III criteria for IBS ; * Patients scheduled for colonoscopy examination or having negative screening examinations * Aged between 18 and 65 years old Exclusion Criteria: * Antibiotic, probiotic or laxative usage within 4 weeks. * organic gastrointestinal diseases * Severe systematic disease: diabetes mellitus, hepatic, renal or cardiac dysfunction, thyroid disease or tumor etc. * pregnancy or lactation. * previous major or complicated abdominal surgery. * severe endometriosis and dementia

Locations (1)

Department of Gastroenterology, Qilu Hospital, Shandong University

Jinan, Shandong, China

RECRUITING

Outcomes

Primary Outcomes

microbiota community among IBS patients in episodes phase,remission phase and healthy controls

Time frame: 5 months

Secondary Outcomes

quality of life in IBS patients

Time frame: 5 months

Central Contacts

Yanqing Li, MD.PhD

CONTACT

86-531-82169236 liyanqing@sdu.edu.cn

Data from ClinicalTrials.gov

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