Pharmacokinetics of Atazanavir /Dolutegravir/Lamivudine Regimen as Maintenance Regimen

Inclusion Criteria: * HIV-infected as documented by positive HIV antibody test and confirmed by Western Blot. * Subject is in need for a switch in maintenance regimen due to adverse effects, toxicities, simplification and/or resistance. * Subject is at least 18 years of age at the day of screening. * Subject is able and willing to sign the Informed Consent Form prior to screening evaluations. * HIV-1 RNA \< 40 copies/mL for at least 6 months on antiretroviral therapy prior to inclusion. * Subject has no documented resistance mutations to PIs, INSTIs or lamivudine. Exclusion Criteria: * Documented history of sensitivity/idiosyncrasy to medicinal products or excipients. * Relevant history or current condition that might interfere with drug absorption, distribution, metabolism or excretion. * Inability to understand the nature and extent of the trial and the procedures required. * Pregnant female (as confirmed by an HCG test performed less than 3 weeks before the first dose) or breast-feeding female. * Abnormal serum transaminases determined as levels being \> 5 times upper limit of normal. * Renal failure determined as an estimated Glomerular Filtration Rate (eGFR) \< 50 ml/min (MDRD-based). * Concomitant use of medications that interfere with atazanavir, dolutegravir or lamivudine pharmacokinetics: oxcarbazepine, phenytoin, phenobarbital, carbamazepine, St. John's wort, rifampicin, clarithromycin, H2 receptor antagonists, proton pump inhibitors, irinotecan, midazolam, triazolam, buprenorphine, aprepitant, modafinil, imatinib, co-trimoxazole, other antiretroviral drugs. * Concomitant use of medications that are contraindicated for use with atazanavir, dolutegravir or lamivudine: alfuzosin, dofetilide, pimozide, quetiapine, quinidine, bepridil, simvastatin, atorvastatin, lovastatin, sildenafil (as for use in pulmonary arterial hypertension), cladribine. * Active hepatobiliary or hepatic disease (including chronic hepatitis B or C infection). * Alcohol abuse.