Minto Model in Effect Site Mode for Target-Controlled Infusion of Remifentanil During Cardiopulmonary Bypass

Seoul National University Hospital56 enrolled

Overview

Target controlled infusion with remifentanil is widely used during cardiac surgery, wich is performed using the Minto model. It was derived from patients undergoing general surgery. However, pharmacokinetics of remifentanil can be changed during cardiopulmonary bypass. The investigators tested whether Minto model for target controlled infusion produces constant plasma remifentanil concentration during the cardiac surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Anesthetics, Intravenous Pharmacology Anesthetics Cardiopulmonary Bypass

Interventions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients with the ASA class I\~III undergoing elective cardiac surgery using cardiopulmonary bypass Exclusion Criteria: * Patients not using target controlled infusion during the operation * Patients with drug/substance abuse * Patients using analgesics before this study starts * Pregnant women * Patients who rejected study participation

Outcomes

Primary Outcomes

Median prediction error

Time frame: during CPB

Secondary Outcomes

changes of measured total remifentanil concentration

Time frame: 1 hour after anesthesia induction, 30/60/90 min after the beginning of cardiopulmonary bypass, 1 hour after the end of cardiopulmonary bypass

Median absolute prediction error