Carbon Monoxide-Saturated Medium for Islet Isolation

Medical University of South Carolina16 enrolled

Overview

The goal of this study is to determine whether harvesting islets using carbon monoxide (CO)-saturated mediums can protect islet cell from death after autologous islet transplantation in patients with chronic pancreatitis.

Investigators plan to harvest human islets using carbon monoxide-saturated mediums. Survival and function of transplanted islets will be compared with islets harvested using regular mediums.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Chronic Pancreatitis

Interventions

Carbon monoxide-bubbled mediumsOTHER

Islets will be harvested with carbon monoxide bubbled mediums

Eligibility

Sex: ALLMin age: 18 YearsMax age: 69 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Chronic pancreatitis patient selected for total pancreatectomy and islet autotransplantation. 2. Age between 18-69. Exclusion Criteria: 1\. Had prior pancreatic surgeries. Note: The study was initially designed only to enroll diabetes free patients. To increase enrollment, we extended the inclusion criteria by allowing patients who are pre-diabetic to participate the study. This revision was approved by the MUSC IRB on 11/10/2015.

Locations (1)

GI Surgery, Medical University of South Carolina

Charleston, South Carolina, United States

Outcomes

Primary Outcomes

Area under the curve during mixed meal tolerance test

Time frame: 6 months

Data from ClinicalTrials.gov

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