Anesthetics agents has variety inflammation during the cancer surgery. This perioperative inflammation can influence to cancer metastasis or recurrence. The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.
The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order. 1. immediate before anesthesia induction 2. postoperative 1 hours 3. postoperative 24 hours Serum in blood will be obtained and activity of helper T cell, natural killer cell and level of serum cytokine will be evaluated by flow cytometry or enzyme-linked immunosorbent assay
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
218
Patient will be anesthetized by using propofol infusion during operation.
Patient will be anesthetized by using sevoflurane inhalation during operation.
Konkuk University Medical Center
Seoul, South Korea
CD39 and CD73 on circulating regualtory T cells
change of percentage of CD39 and CD73 (scores range from 0 to 100)
Time frame: preoperative time. postoperative 1 hours and 24 hours
Circulating natural killer cells
change of percentage of circulating natural killer cell (scores range from 0 to 100)
Time frame: preoperative time. postoperative 1 hours and 24 hours
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