Dexketoprofen and Etoricoxib in Patients Undergoing Hip Arthroplasty

Kuopio University Hospital24 enrolled

Overview

The main purpose of this study was to determine the plasma and central nervious system pharmacokinetics of dexketoprofen and etoricoxib. The secondary aim was to asses their effect on the concentrations of interleukin 6, prostaglandin E2 and other proinflammatory markers both in plasma and cerebrospinal fluid. Thirdly, the investigators aimed to evaluate their efficacy in postoperative pain treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Pain, Postoperative

Interventions

DexketoprofenDRUG

After total hip replacement surgery patient were given either etoricoxib or dexketoprofen

EtoricoxibDRUG

After total hip replacement surgery patient were given either etoricoxib or dexketoprofen

Eligibility

Sex: ALLMin age: 40 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * agreed to participate the study * American Society of Anesthesiologist s physical status classification 1-3 * elective hip arthroplasty planned * no contraindications to the study drugs * no contraindication to lumbar puncture Exclusion Criteria: * refused to participate the study * age less than 40 or over 75 years * Planned anesthesia method other than spinal anesthesia * contraindications to the study drugs * Contraindications to lumbar puncture

Outcomes

Primary Outcomes

Cerebrospinal fluid concentration dexketoprofen and etoricoxib

Cerebrospinal fluid concentration of dexketoprofen and etoricoxib

Time frame: 0-24 hours

Plasma concentration dexketoprofen and etoricoxib

Time frame: 0-24 hours

Secondary Outcomes

Pain

Pain assessed with numeral rating scale

Time frame: 0-24 h

Data from ClinicalTrials.gov

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