To determine whether high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients (eg, ω-3 fatty acids and antioxidants) enriched with β-glucan stimulates immune functions compared with standard enteral nutrition (control: 20% of total calorie from protein) or high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients without β-glucan in critically ill patients.
To determine whether high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients (eg, ω-3 fatty acids and antioxidants) enriched with β-glucan stimulates immune functions compared with standard enteral nutrition (control: 20% of total calorie from protein) or high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients without β-glucan in critically ill patients. In a randomized double-blind placebo-controlled study, 30 patients consumed 1 of 3 enteral nutrition: control, enteral nutrition of immune modulating nutrients enriched with β-glucan (250mg/L) or enteral nutrition of immune modulating nutrients without β-glucan. Enteral nutrition was initiated within 24 hours of ICU admission and continued during the ICU stay for a 7 days.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
Enrollment
30
standard enteral nutrition
high-protein enteral nutrition of immune modulating nutrients enriched with β-glucan
high-protein enteral nutrition of immune modulating nutrients without β-glucan
Change from baseline NK cell activity at 7 days
NK cell activity (%)
Time frame: at baseline and 7 days follow-up
Change from baseline IL-12 at 7 days
IL-12 (pg/mL)
Time frame: at baseline and 7 days follow-up
Change from baseline hs-CRP at 7 days
hs-CRP (mg/dL)
Time frame: at baseline and 7 days follow-up
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