Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States

Inclusion Criteria: 1. Male and female help seeking individuals aged between 16-35 years. 2. Meets at least one of the criteria for ARMS (see CAARMS Operationalized Intake Criteria section below). 3. Assessed as competent to provide informed consent. Exclusion Criteria: 1. History ofpreviously experiencing a psychotic illness (treated or untreated). 2. IQ \< 70 and/or history of learning disability. 3. Any pre-existing inflammatory conditions e.g. rheumatoid arthritis. 4. Organic brain disease e.g. epilepsy. 5. treatment with an antipsychotic or mood-stabilising agent. 6. Prior history of intolerance or serious side effects (hepatotoxicity, photosensitivity, blood dyscrasias) to any of the tetracyclines or Omega-3 fatty acids. 7. Concomitant penicillin therapy or concomitant anticoagulant therapy. 8. Active substance abuse (except nicotine or caffeine) or dependence within the last three months, according to DSM-V criteria. 9. Treatment with warfarin or lamotrigine. 10. Current or previous treatment with tetracycline antibiotics or Omega-3 fatty acids in the preceding three months before study entry. 11. Current treatment with any anti-inflammatory medication. 12. Treatment with electroconvulsive therapy within the 12 weeks preceding the study. 13. Active expression of suicidal ideation (CAARMS item 7.3 severity score 6) or current aggression/dangerous behaviour (CAARMS item 5.4 severity score 6). 14. Relevant current or past hematologic, hepatic, renal, neurological or other medical disorder that in the opinion of the principal investigator may interfere with the study. 15\. Pregnant or breastfeeding females.