This is a randomized controlled study of non-damaging photothermal macular grid laser versus sham laser therapy in patients with dry age-related macular degeneration (AMD) and large high-risk drusen. The goal of the study is to determine if this treatment will reduce macular drusen volume and also whether this might improve visual acuity or reduce the risk of conversion to advanced age-related macular degeneration defined as development of choroidal neovascularization or geographic atrophy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
19
Sub-threshold macular laser treatment with Pascal laser Endpoint Management System
Byers Eye Institute at Stanford University
Palo Alto, California, United States
Change in Macular Drusen Volume
Mean change in macular drusen volume as measured on high-resolution spectral domain ocular coherence tomography (SD-OCT)
Time frame: baseline, 6, 12, and 24 months
Change in Visual Acuity
Mean change in best-corrected visual acuity as measured using early treatment diabetic retinopathy study (ETDRS) chart - average number of letters seen on chart
Time frame: baseline, 6, 12, and 24 months
Development of Geographic Atrophy (GA) or Choroidal Neovascularization (CNV)
Count of eyes that develop geographic atrophy or choroidal neovascularization by 24 months.
Time frame: 2 years
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