Efficacy of Fluoxetine Against Seizure-induced Central Apneas

Inclusion Criteria: Patient suffering from drug-resistant focal epilepsy * Age ≥ 18 years * Patient for whom a video-EEG monitoring of their seizures was scheduled as part of a pre-surgical assessment * For women of childbearing age, a method of contraception considered effective by the investigator * Patient who have given their written informed consent * Patient accepting an interview with a psychologist and to be refered to a psychiatrist in the event that mood disorders were detected on mood scores and considered severe by the investigator and / or psychologist, leading to require psychiatric care or immediate antidepressant treatment * Patient with a social security number Exclusion Criteria: * Age \< 18 years * Patient under legal protection * Pregnant or breastfeeding women * Hypersensitivity to fluoxetine or its excipients * History of other serious side effects related to an earlier prescription of fluoxetine; * Current suicidal ideation or history of suicide attempt * Manic episode * Disruption of liver enzymes considered material by the investigator using the following criteria: transaminases (ALT and AST)\> 2N alkaline phosphatase (ALP)\> 2N gamma glutamyl transpeptidase (GGT)\> 5N (performed as part of routine monitoring of epileptic patients on antiepileptic treatment. Patients often exhibit changed deemed clinically insignificant due to the enzyme-inducing effect of these drugs) * Renal failure with creatinine clearance \<30 ml / min * Acute heart disease * Antidepressant treatment * Other prohibited treatment (see detailed list in protocol).