Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Mahidol University32 enrolled

Overview

Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills. Spinal morphine is alternative simple method with less efficacy. Adding low dose ketamine during intraoperative may be helpful in postoperative pain relief.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Pain Postoperative Period

Interventions

NSSOTHER

NSS infusion

KetamineDRUG

Ketamine 0.2 mg/kg/hr intravenous infusion

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA physical status 1-3 * elective thoracotomy * can operate patient-controlled analgesia (PCA) machine Exclusion Criteria: patient with history of * allergy to morphine or ketamine * contraindicate to ketamine * remain intubated in the postoperative period

Locations (1)

Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University

Bangkok, Thailand

Outcomes

Primary Outcomes

Time to first trigger of morphine

Time frame: 24 hours

Secondary Outcomes

24-hr morphine consumption

Time frame: 24 hours

NRS score at 6, 24 hours

NRS score (0-10) was assessed at at 6, 24 hours postoperative

Time frame: 24 hours

Incidence of nausea and vomiting

Time frame: 24 hours

Data from ClinicalTrials.gov

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