Mannitol Versus Supportive Care in Ciguatera Fish Poisoning

University of South Florida200 enrolled

Overview

Ciguatera poisoning, caused by the ingestion of ciguatoxin-containing fish, is a global public health concern. In the US, the vast majority of ciguatera poisonings occur in Florida, followed by Hawaii and California. Equipoise exists in the medical literature regarding the effectiveness of mannitol therapy in treatment of ciguatera poisoning. While there are many case reports attesting to its utility, the only randomized control trial (RCT) comparing mannitol therapy with supportive care failed to show any significant benefit from mannitol treatment for a variety of clinical outcomes. Investigators therefore propose a second, larger RCT to test this question.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

200

Conditions

Ciguatoxin

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * History consistent with ciguatera poisoning Exclusion Criteria: * Minors * pregnant patients * those unable to give consent * severe congestive heart failure or renal failure

Outcomes

Primary Outcomes

Symptom score

Covers a variety of neurological and gastrointestinal symptoms on a 0-4 score

Time frame: 24 hours

Central Contacts

Michael Butterfield, MD MS MPH

CONTACT

mbutterfield@health.usf.edu

Data from ClinicalTrials.gov

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