A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation

Inclusion Criteria: * Korean male aged between 19 and 65 * Both patient and his partner given their informed and written consents * Patient who has persisted for at least 6 months and is willing to retain the relationship during this study * Patient diagnosed with premature ejaculation according to DSM-V * Patient whose score in PEDT (Korean version) is 11 and more * Patient who are willing to try 4 and more intercourse attempts for Run-in period and he has experienced 75%-100% of the IELT within one minute or less of vaginal penetration * Patient whose personal distress in PEP is 'moderate' and over. * Patient who is willing to participate in the study by the end and are cooperative (trying 4 and more intercourse attempts between each visit and able to postpone scheduled elective surgery) * Patient who is willing to complete a patient diary and questionnaires Exclusion Criteria: * Patient who has a medical history including neurological disorders, infectious diseases, damage, surgery or medication history and that is judged to be related to premature ejaculation * Patient who has participated into other trials within 90 days before this study * Patient who is in a unstable medical condition or has alcohol/drug abuse in recent 6 months * Patient whose female partner is less interested in sexual intercourse or has a sexual disorder * Patient whose female partner is pregnant * Patient whose female partner of childbearing age is not willing to use proper birth control * Patient whose IIEF-EF score is 25 and less * Medical history of convulsive diseases, mental diseases, E.C.T (Electroconvulsive shock Treatment), glaucoma * Patient who has taken concomitantly prohibited medicines before the study and who is not willing to stop the medications for appropriate wash-out period