Secondary Cancer Risk After Radiation Therapy for Rectal Cancer

Kantonsspital Graubünden25 enrolled

Overview

Retrospective study comparing dose distribution of 3D conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT) to estimate secondary cancer risk for patients having had radiation therapy for rectal cancer. Twenty-five patients are included in this study. Planning CT scans are used for comparison of dose distribution and calculation of second cancer risk.

A model-based Analysis calculating the organ-specific excess lifetime attributable risk using the planning CT data sets of 25 patients to estimate second cancer risk for patients after radiotherapy for rectal cancer comparing conventional 3DCRT with VAMT techniques.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Neoplasms, Second Primary

Interventions

No intervention in this retrospective studyOTHER

No Intervention in this retrospective Analysis. All patients included did receive Radiation therapy Independent of this study

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male/Female \> 18 years of age * pre or postoperative radiation therapy for rectal cancer * Planning CT Exclusion Criteria: * Planning CT not available

Locations (1)

Klinik Hirslanden, Institute for Radiotherapy

Zurich, Switzerland

Outcomes

Primary Outcomes

Calculation of the organ-specific excess lifetime attributable risk (LAR) (%)

LAR is calculated for variable Ages at exposure

Time frame: 60 years (model-based calculation)

Data from ClinicalTrials.gov

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