Phase II Study Evaluating the Efficacy of Aflibercept for the Treatment of Choroidal Neovascularization in Angioid Streaks in Young Patients (ASTRID).

Inclusion Criteria: * 18 \< Age \< 50 years old * Patient who give voluntary signed informed consent * Patient affiliated with the French universal health care system or similar * Patient with CNV in angioid streaks, whatever caused the angioid streaks, with active primary subfoveal, retrofoveal or juxtafoveal lesions that affect the fovea as evidenced by angiography (fluorescein and/or indocyanine green) and/or SD-OCT in the studied eye * Patient willing, committed and able to return for all clinic visits and complete all study-related procedures Exclusion Criteria: * Pregnant women * Sexually active men or women of childbearing potential who are unwilling to practice adequate contraception during the study * Patient who is protected adults according to the terms of the law (French public health laws) * Involvement in another clinical trial (studied eye and/or the other eye) * Patient with non-angioid streaks CNV, especially: * AMD * High myopia defined as refraction ≥ - 6 diopters * Other curative treatment of CNV in angioid streaks in the studied eye during the last 3 months before the first intravitreal injection: anti-VEGF therapy, juxta- or extra-foveal macular laser, photodynamic therapy, surgery, external radiotherapy, transpupillary thermotherapy ... * Medical history of retrofoveal focal macular laser photocoagulation in the studied eye * Subretinal hemorrhage reaching the fovea center or with a size \> 50% of the lesion area * Fibrosis or retrofoveal retinal atrophy in the studied eye * Retinal pigment epithelial tear reaching the macula in the studied eye * Medical history of intravitreal medical device in the studied eye * Medical history of auto-immune or idiopathic uveitis * Proved diabetic retinopathy * Intra-ocular pressure ≥ 25 mmHg despite two topical hypotonic treatments * Aphakia or lack of lens capsule (not removed by YAG laser) in the studied eye * Arterial hypertension that is not controlled by an appropriate treatment and defined by one measure of systolic blood pressure \> 180mmHG or 2 consecutive measures \> 160mmHg, or by a diastolic blood pressure \> 100mmHg * Antecedents of cerebrovascular disease or myocardial infarction during the last 6 months before inclusion (J1) * Antecedents of any pathology, metabolic disease, or any serious suspicion of disease during the clinical or laboratory exam that would contraindicate the use of the product, could affect the interpretation of the study results or lead to major risks of complication for the subject * Renal insufficiency requiring dialysis or renal transplantation * Previous (less than a year) or actual treatment with systemic administration of anti-VEGF therapy * Known hypersensitivity to aflibercept, or another drug composite of the medicinal product used; allergy to fluorescein, indocyanine green, anaesthetic eye drops * Active or suspected ocular or peri-ocular infection * Active severe intraocular inflammation * Medical history of intra-ocular surgery within 28 days before the first injection in the studied eye * Any illness or ocular condition that would require an intra-ocular surgery in the studied eye within 12 months after the inclusion * Follow up not possible during 12 months