Pain Relief In Irritable Bowel Syndrome

Inclusion Criteria: 1. patients over 18 y.o. 2. clinical diagnosis of IBS following Rome III symptom- based criteria: 1. abdominal pain or discomfort recurring for at least 3 days a month in the previous 3 months, associated with 2 of the following characteristics at least: improved with evacuation; onset associated with variation of stool frequency; onset associated with changes in stool consistency 2. onset of symptomatology at least 6 months preceding diagnosis 3. additional criterion: mean severity of abdominal pain higher than 3 in the 11-points NRS 3. For patients over 50 y.o. or with positive familiarity for colorectal cancer: normal colonoscopy performed within 5 years from the beginning of the screening's period and after symptomatology's onset 4. For patients over 65 y.o. : absence of ischemic / microscopic colitis, or other organic gastrointestinal disorders, as highlighted through colonoscopy with biopsy performed within 6 months from the beginning of the screening's period 5. For fertile and sexually active women: use of effective contraception with failure rate of less than 1% for one year during the trial period and 30 days after its end. Oral contraceptive are admitted as long as formulation didn't undergo changes during the 6 months preceeding the trial. 6. Physical examination is negative during the period of screening 7. Absence of significant alterations in 12- lead ECG during the period of screening. 8. Normal haematochemical parameters during the period of screening 9. Compliant patients towards procedures provided for the study, especially the use of daily diary 10. Patients with mental integrity, able to express an informed before any procedure related to protocol, compliant toward clinical examinations provided for the protocol. 11. Patients willing to avoid loperamide and laxatives use during the 3 days preceding run in and during the whole run in's period ( to be verified before randomization) 12. Patients that during both the 2 run in's weeks reported an average daily intensity of abdominal pain for every week \>3 on 0-10 (NRS) Exclusion Criteria: 1. Male gender 2. Patient has a diagnosis of IBS with a subtype of constipation, mixed IBS, or unsubtyped IBS according to the Rome III criteria 3. Patient has had surgery that meets any of the following criteria: a) colonic or major abdominal surgery, i.e. bariatric surgery and stomach, small/ large bowel or large vessel abdominal surgery ( except appendicectomy, hysterectomy, cholecystectomy, caesarean section, or laparoscopic surgery). 4. Patient has any elective major surgery planned or expected at any time during the study. 5. Patient has a history of inflammation bowel diseases, complicated diverticulosis ( i.e. diverticulitis), ischaemic colitis, microscopic colitis. 6. Patient has a history of organic abnormalities of the GI tract, intestinal obstruction, stricture, toxic megacolon, GI perforation, fecal impaction, gastric banding, adhesions or impaired intestinal circulation ( e.g., aortoiliac disease). 7. Patient has a history of pancreatitis of any etiology, cholecystitis or of symptomatic gallbladder stone disease in the previous 6 months. 8. Patient has an active biliary duct disease of a history of Sphincter of Oddi dysfunction. 9. Patient has a history of gluten enteropathy. 10. Patient has a history of lactose intolerance as assessed by response to diet. 11. Patient has a current or previous diagnosis of neoplasia ( except non-GI) neoplasia in complete remission \< or = 5 years, squamous and basal cell carcinomas and cervical carcinoma in situ). 12. Patient has a history of ectopic endometriosis. 13. Patient has a history of positive tests for ova or parasites, or clostridium difficile toxin or occult blood in the stool in the previous 6 months. 14. Patient has a history of human immunodeficiency virus infection. 15. Patient has a history of a cardiovascular event, including stroke, myocardial infarction, congestive heart failure ( NYHA class \> 2), or transient ischemic attack in the previous 6 months. 16. Patient has uncontrolled hypertension, defined as systolic blood pressure \<180 mmHg or a diastolic blood pressure \< 100 mmHg. 17. Patient has insulin- dependent diabetes mellitus. 18. Patient has a major pshychiatric or neurological disorders. 19. Patient has an unstable medical condition which may compromise the efficacy and safety assessments as required in the study and/or require change in concomitant medication. 20. Patient has a history of abnormal thyroid function. Patient is candidate for the study if thyroid hormone replacement therapy is stable from at least 2 months. 21. Patient has evidence of clinically hepatic disease as defined by alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>3 times rthe upper limit of normal or total bilirubin \>3 mg/dl (\>51.3 mmoL/L), with the exception of Gilbert's syndrome or albumin \< 2.8 g/dL during the Screening period. 22. Patient has a sever renal insufficiency ( Glomerular Filtration Rate \[GFR\] \<30 mL/min/ 1.73 m\^2 calculated by the Cockcroft. Gault formula adjusted for the body surface area \[BSA\]) during the Screening period 23. Patient has evidence of anemia as confirmed by hemoglobin \< 9 g/dL during the Screening period. 24. Relevant changes in dietary habits, lifestyle or exercise regimen should be maintained for the duration of the study. 25. Use of prohibited concurrent medication within the previous month, namely: * Antibiotics ( 4 months in the case of rifaximin); * 5- HT3 antagonists alosetron. 26. Use of prohibited concurrent medication in the previous 7 days namely: * Antimuscarinic drugs; * Drug enhancing GI motility such as prokinetic agents and other stimulants of GI contractility drugs, laxatives, or anti- diarrhoeal agents ( except for loperamide, please refer to inclusion criterion No.12); * Analgesic drugs ( opioids or non- steroidal anti- inflammatory drugs). NOTE: short term use of paracetamol is allowed for max 2 consecutive days; * Fibre products and herbal preparations; * Antidepressants. NOTE: the use of a single antidepressant is only allowed when the drug type and its dose regimen have not been changed in the previous 6 months; * Benzodiazepines. NOTE: the use of a single benzodiazepine is only allowed when it is administered as sleep- inducer and the drug type and its dose regimen have not been changed in the previous 6 months. 27. Pregnancy or breastfeeding. 28. Hypersensitivity to the drug excipients. 29. Patient is not able to understand or collaborate throughout the study. 30. Patient is unable to swallow solid, oral dosage forms whole with the aid of liquid ( patients may not chew, divide, dissolve, or crush the study drug). 31. Partecipation in other clinical studies in the previous 4 weeks or the patient is currently enrolled in a clinical study with another investigational drug. 32. Patient has any condition that, in the opinion of the Investigator, would compromise the well- being of the patient or the requirements of the study.