A Study to Characterise the Antimalarial and Transmission Blocking Activity of a Single Dose of DSM265 or OZ439 in Healthy Subjects With Induced Blood Stage Plasmodium Falciparum or Plasmodium Vivax Infection

Inclusion Criteria: Health status: * Certified as healthy by a comprehensive clinical assessment (detailed medical history and complete physical examination). * Normal vital signs after 5 minutes resting in supine position: * 90 mmHg \< systolic blood pressure (SBP) \<140 mmHg, * 50 mmHg \< diastolic blood pressure (DBP) \<90 mmHg, * 40 bpm\< heart rate (HR) \<100 bpm. * Normal standard 12-lead electrocardiogram (ECG) after 5 minutes resting in supine position, QTcF≤450 ms (males and females) with absence of second or third degree atrioventricular block or abnormal T wave morphology. * Laboratory parameters within the normal range, unless the Investigator considers an abnormality to be clinically irrelevant for healthy participants enrolled in this clinical investigation. More specifically for serum creatinine, hepatic transaminase enzymes (aspartate aminotransferase, alanine aminotransferase), and total bilirubin (unless the Participant has documented Gilbert syndrome) should not exceed the upper laboratory norm and haemoglobin must be equal or higher than the lower limit of the normal range * As there is the risk of adverse effects of the investigational drugs (DSM265 and OZ439), and standard curative treatment (Riamet and primaquine - cohort 1 only) in pregnancy, it is important that any participants involved in this study do not get pregnant or get their female partners pregnant (refer to Section 6.7). For cohort 1 and 3 (treatment with DSM265): Female participants of childbearing potential (WOCBP) may be enrolled in the DSM265 cohorts but must have adequate contraception in place for the duration of the study and up to 60 days (9 weeks) after the last dose of DSM265, with adequate contraception defined as: * Stable hormonal contraception (with an approved oral, transdermal or depot regimen) for at least 3 months prior to screening i.e. oral contraceptives, either combined or progestogen alone, hormonal implantable contraception, vaginal ring, contraceptive patches * Intrauterine (IUD) device or system in place for at least 3 months prior to screening * Male partner sterilization prior to the female participant's entry into the study, and this male is the sole partner for that participant Abstinent female participants must agree to start a double method if they start a sexual relationship during the study and for up to 60 days (9 weeks) following the last dose of DSM265. Male participants to be dosed with DSM265 in cohort 1 or 3 must agree to use a double method of contraception including condom plus diaphragm or condom plus stable oral/transdermal/injectable hormonal contraceptive by female partner from at least 14 days prior to the time of the dose of the study drug through 120 days (17 weeks) after the last dose of DSM265. Abstinent male participants must agree to start a double method if they start a sexual relationship during the study and for up to 120 days (17 weeks) weeks following the last dose of DSM265. For cohort 2 (treatment with OZ439): Female subjects must be considered as women of not childbearing potential (WONCBP) to be eligible. WONCBP is defined as: * Spontaneous amenorrhoea for at least 1 year or spontaneous amenorrhea for at least 6 months confirmed by an FSH result above the laboratory defined range for post-menopausal * or permanently sterilised (eg tubal occlusion, hysterectomy, bilateral salpingectomy) Female subjects with same sex partners (abstinence from penile-vaginal intercourse), are eligible when this is their preferred and usual lifestyle. Male participants to be dosed with OZ439 in cohort 2 must agree to use a double method of contraception including condom plus diaphragm or condom plus stable oral/transdermal/injectable hormonal contraceptive by female partner from at least 14 days prior to the time of the dose of the study drug through 96 days (14 weeks) after the last dose of OZ439. Abstinent male participants must agree to start a double method if they start a sexual relationship during the study and for up to 96 days (14 weeks) following the last dose of OZ439. For Part B only (cohort 2 and 3): \- All subjects must be Duffy Blood group positive. Female subjects of childbearing potential (Cohort 3 only) should be blood group Rh positive. Regulations: \- Having given written informed consent prior to undertaking any study-related procedure. Exclusion Criteria: Medical history and clinical status: * Any history of malaria or participation to a previous malaria challenge study * Must not have travelled to or lived in a malaria-endemic country during the past 12 months or planned travel to a malaria-endemic country during the course of the study. * Has evidence of increased cardiovascular disease risk (defined as \>10%, 5 year risk) as determined by the Australian Absolute Cardiovascular Disease Risk Calculator (http://www.cvdcheck.org.au/). Risk factors include sex, age, systolic blood pressure (mm/Hg), smoking status, total and HDL cholesterol (mmol/L), and reported diabetes status. * History of splenectomy. * Presence or history of drug hypersensitivity, or allergic disease diagnosed and treated by a physician or history of a severe allergic reaction, anaphylaxis or convulsions following any vaccination or infusion. * Presence of current or suspected serious chronic diseases such as cardiac or autoimmune disease (HIV or other immunodeficiencies), insulin-dependent and non-insulin dependent diabetes, progressive neurological disease, severe malnutrition, acute or progressive hepatic disease, acute or progressive renal disease, psoriasis, rheumatoid arthritis, asthma, epilepsy or obsessive compulsive disorder * History of malignancy of any organ system (other than localized basal cell carcinoma of the skin or in situ cervical cancer), treated or untreated, within 5 years of screening, regardless of whether there is evidence of local recurrence or metastases * Participants with history of schizophrenia, bi-polar disease, or other severe (disabling) chronic psychiatric diagnosis including depression or receiving psychiatric drugs or who has been hospitalized within the past 5 years prior to enrollment for psychiatric illness, history of suicide attempt or confinement for danger to self or others. * Frequent headaches and/or migraine, recurrent nausea, and/or vomiting (more than twice a month) * Presence of acute infectious disease or fever (e.g., sub-lingual temperature ≥ 38.5°C) within the five days prior to inoculation with malaria parasites. * Evidence of acute illness within the four weeks before trial prior to screening that the Investigator deems may compromise subject safety. * Significant inter-current disease of any type, in particular liver, renal, cardiac, pulmonary, neurologic, rheumatologic, or autoimmune disease by history, physical examination, and/or laboratory studies including urinalysis. * Participant has a clinically significant disease or any condition or disease that might affect drug absorption, distribution or excretion, e.g. gastrectomy, diarrhoea. * Participation in any investigational product study within the 12 weeks preceding the study. * Blood donation, any volume, within 1 month before inclusion or participation in any research study involving blood sampling (more than 450 mL/ unit of blood), or blood donation to Red Cross (or other) blood bank during the 8 weeks preceding the reference drug dose in the study. * Participant unwilling to defer blood donations to the Australian Red Cross Blood Service (ARCBS) for 6 months. * Medical requirement for intravenous immunoglobulin or blood transfusions. * Participant who has ever received a blood transfusion. * Symptomatic postural hypotension at screening, irrespective of the decrease in blood pressure, or asymptomatic postural hypotension defined as a decrease in systolic blood pressure ≥20 mmHg within 2-3 minutes when changing from supine to standing position. * History or presence of alcohol abuse (alcohol consumption more than 40 g per day) or drug habituation, or any prior intravenous usage of an illicit substance. * Smoking more than 5 cigarettes or equivalent per day and unable to stop smoking for the duration of the study. * Ingestion of any poppy seeds within the 24 hours prior to the screening blood test (participants will be advised by phone not to consume any poppy seeds in this time period). * Excessive consumption of beverages containing xanthine bases, including Red Bull, chocolate etc. more than 400 mg caffeine per day (equivalent to more than 4 cups per day) Interfering substance: * Any medication (including St John's Wort) within 14 days before inclusion or within 5 times the elimination half-life (whichever is longer) of the medication * Any vaccination within the last 28 days. * Any corticosteroids, anti-inflammatory drugs, immunomodulators or anticoagulants. Any participant currently receiving or having previously received immunosuppressive therapy, including systemic steroids including adrenocorticotrophic hormone (ACTH) or inhaled steroids in dosages which are associated with hypothalamic-pituitary-adrenal axis suppression such as 1 mg/kg/day of prednisone or its equivalent or chronic use of inhaled high potency corticosteroids (budesonide 800 μg per day or fluticasone 750 μg). * Any recent (\< 6 weeks) or current systemic therapy with an antibiotic or drug with potential anti-malarial activity (i.e. chloroquine, piperaquine, benzodiazepine, flunarizine, fluoxetine, tetracycline, azithromycin, clindamycin, hydroxychloroquine, etc.) General conditions: * Any participant who, in the judgment of the Investigator, is likely to be noncompliant during the study, or is unable to cooperate because of a language or mental deficit. * Any participant in the exclusion period of a previous study according to applicable regulations. * Any participant who lives alone (from Day 0 until at least the end of the anti-malarial drug treatment). * Any participant who cannot be contacted in case of emergency for the duration of the trial and up to 2 weeks following end of study visit. * Any participant who is the Investigator or any sub-investigator, research assistant, pharmacist, study coordinator, or other staff thereof, directly involved in conducting the study. * Any participant without a good peripheral venous access. Biological status * Positive result on any of the following tests: hepatitis B surface (HBs Ag) antigen, anti-hepatitis B core antibodies (anti-HBc Ab), anti-hepatitis C virus (anti-HCV) antibodies, anti-hepatitis A or E virus (IgM) antibodies, anti-human immunodeficiency virus 1 and 2 antibodies (anti-HIV1 and anti HIV2 Ab) * Any drug listed in Table 2 (Drug Screening) in the urine drug screen unless there is an explanation acceptable to the medical investigator (e.g., the participant has stated in advance that they consumed a prescription or OTC product which contained the detected drug) and/or the Participant has a negative urine drug screen on retest by the pathology laboratory. Specific to the study\_ * Cardiac/QT risk * Family history of sudden death or of congenital prolongation of the QTc interval or known congenital prolongation of the QTc interval or any clinical condition known to prolong the QTc interval. * History of symptomatic cardiac arrhythmias or with clinically relevant bradycardia. Electrolyte disturbances, particularly hypokalaemia, hypocalcaemia, or hypomagnesaemia. * Electrocardiogram (ECG) abnormalities in the standard 12-lead ECG (at screening) which in the opinion of the Investigator is clinically relevant or will interfere with the ECG analyses on study * Known hypersensitivity to DSM265 or OZ439, or any of its excipients or 4-aminoquinolines, artemether or other artemisinin derivatives, lumefantrine, or other arylaminoalcohols. * Known severe reaction to mosquito bites other than local itching and redness. * Unwillingness to abstain from consumption of citrus (grapefruit, Seville orange, etc.) for ≥21 days prior to initiation of the study (inoculation; Day 0) and for the study duration. * Unwillingness to abstain from consumption of quinine containing foods/beverages such as tonic water, lemon bitter, from inoculation (Day 0) to the end of the malaria treatment. * Any history or presence of lactose intolerance. * Use of prescription drugs, herbal supplements, within four weeks prior to administration of the study drug, and/or over-the-counter (OTC) medication, dietary supplements (including vitamins) within two weeks prior to initial dosing (Note: diazepam interferes with the analysis of blood levels of DSM265 and thus should not have been used for at least 8 weeks prior to administration of the study drug). If needed (i.e. an incidental and limited need) paracetamol is acceptable up to 4 g/day. Participants are requested to refrain from taking non-approved concomitant medication from recruitment until the conclusion of the study. Participants who are excluded from participation on study days for any of the above reasons may be eligible to participate on a postponed schedule if the Investigator considers this appropriate.