Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery

Kuopio University Hospital180 enrolled

Overview

In the present study, the primary aim was to evaluate if oxycodone-naloxone combination compared to oxycodone reduced opioid induced constipation in patients with or without chronic opioid treatment undergoing spine surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

180

Conditions

Constipation

Interventions

oxycodone-naloxoneDRUG

OxycodoneDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * BMI 17 - 35 kg/m2 * elective spine surgery * informed consent obtained Exclusion Criteria: * allergy to the used drugs * other contraindication to oxycodone medication * no informed consent

Locations (1)

Kuopio University Hospital

Kuopio, Northern Savonia, Finland

Outcomes

Primary Outcomes

opioid induced constipation

Opioid induced constipation was assessed with bowel function index

Time frame: from the surgery up to 21 days

Data from ClinicalTrials.gov

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