Skeletal Muscle Energy Metabolism in Undernourished Patients With Gastrointestinal Cancer

University Hospital, Tours51 enrolled

Overview

Undernutrition associated with cancer, or cancer cachexia results from a deterioration of the energy balance that leads to a gradual mobilization of energy reserves in the body and to increasing deterioration of the nutritional status of patients. This will thus significantly reduce quality of life and survival of patients with a lower tolerance to cancer treatments. Despite undeniable progress in knowledge, many pathophysiological mechanisms remain few or not explored, which could explain that there is still no satisfactory therapeutic solution to halt the gradual deterioration of the nutritional status of patients. In this sense, apart from preclinical data obtained in animal models, there is currently no clinical study on the functioning of skeletal muscle energy metabolism in undernourished patients suffering of cancer.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Undernutrition Gastrointestinal Cancer

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Case group selection criteria: Inclusion Criteria: * 18 years ≤ Age ≤ 80 years * Colorectal pancreatic cancer * Undernutrition related to cancer (weight loss \> 5% weight in one month or 10% in 6 months) * Indication to systemic chemotherapy * Indication to the development of an implantable port * Life expectancy ≥ 3 months * WHO General Status ≤ 2 * Patients affiliated to social security scheme * Informed consent signed by the patient Exclusion Criteria: * Pregnant or breastfeeding women * Unbalanced Diabetes * Systemic corticosteroid treatment * Any severe uncontrolled medical condition * Alopecia Control group selection criteria: Inclusion Criteria: * 18 years ≤ Age ≤ 80 years * Colorectal pancreatic cancer * Indication adjuvant chemotherapy * Indication to the development of an implantable port * Life expectancy ≥ 3 months * WHO General Status ≤ 2 * Patients affiliated to social security scheme * Informed consent signed by the patient Exclusion Criteria: * Pregnant or breastfeeding women * Undernutrition related cancer (weight loss \> 5% weight in one month or 10% in 6 months) * Unbalanced Diabetes * Systemic corticosteroid treatment * Any severe uncontrolled medical condition * Alopecia

Outcomes

Primary Outcomes

Measurement of muscle mitochondrial bioenergetics

Measurement of muscle mitochondrial bioenergetics by high resolution oxygraphy

Time frame: An average of one week

Secondary Outcomes

Quantification of muscle lipid droplets

Quantification of muscle lipid droplets by electron microscopy

Time frame: An average of one week

Analysis of the expression of target genes and proteins

Analysis of the expression of target genes and proteins involved in 1/ mitochondrial metabolism 2/ lipid metabolism 3/ the regulation of energy metabolism and 4/ muscle proteolysis by RTqPCR with SYBR Green and by Western Blot

Time frame: An average of one week

Determination of body composition (fat mass / lean mass)

Determination of body composition ( fat mass / lean mass ) by an imaging method scannographic

Time frame: Within 4 weeks before inclusion

Determining the isotopic composition of nitrogen hair

Determining the isotopic composition of nitrogen hair spectrometry .

Time frame: An average of one week

Skeletal Muscle Energy Metabolism in Undernourished Patients With Gastrointestinal Cancer

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes