Oat Phenolics Bioavailability

University of Reading7 enrolled

Overview

A diet rich in whole grain is inversely associated with cardiovascular disease risk and this benefit could be partly attributed to the phenolic acid content of whole grains. The exact absorption, metabolism and excretion of whole grain phenolic acids, however, is not fully understood. In a small human intervention trial, the investigators will investigate to what extent phenolic acids from whole grain oats are absorbed, excreted in urine and how they are metabolised.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Oat branDIETARY_SUPPLEMENT

66g oat bran made up in 350ml skimmed milk

refined grainDIETARY_SUPPLEMENT

refined grain product and 350ml skimmed milk

Eligibility

Sex: MALEMin age: 25 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Males * 25 to 65 years old Exclusion Criteria: * Allergies to oats * Parallel participation in another research project * Having flu vaccination or antibiotics within 3 months of trial start * Taking food supplements within 3 months of trial start * Past or existing medical history of vascular disease, diabetes, hepatic, renal, gastrointestinal, haematological, neurological, thyroidal disease or cancer

Locations (1)

Department of Food and Nutritional Sciences

Reading, Berkshire, United Kingdom

Outcomes

Primary Outcomes

Change from baseline in phenolic acid metabolite excretion

Time frame: Baseline and 48 hours

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.