Study of Motor Representations in Healthy Subjects and Amnestic MCI

University Hospital, Angers97 enrolled

Overview

Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.

Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mild Cognitive Impairment

Interventions

Brain MRIRADIATION

Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures. Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk. The GAITRite is a carpet for recording the walking operating parameters

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Obtaining the signature of consent to participation in the study * Age above 18 years * Lack dementia as NICDS-ADRDA criteria * Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI). * Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae. * No cons-indication for performing a brain MRI. * Witennses, population of young (\<40 years) * Witnesses ,population of older subjects (\> 60 years) * Witnesses Lack of MCI * MCI patients, criteria MCI criteria according to Dubois Exclusion Criteria : * Refusal of MRI. * Contraindications to brain MRI.

Locations (1)

University Hospital Angers

Angers, Pays de la Loire Region, France

Outcomes

Primary Outcomes

Review and compare mapping cerebral activation in brain MRI

Review and compare mapping brain activation in healthy about MRI according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination the walk. The primary endpoint is the analysis of fMRI brain mapping in accordance with the different paradigms of acquisition. The MRI data will be the subject of a specific statistical treatment, via dedicated software, which will be implemented under the control of the investigators who have conducted such an fMRI analysis in previous studies. Various brain mapping can be established from the data collected. It may include statistical comparisons between different preselected regions, and different experimental conditions, or correlation studies between brain activation and clinical parameters.

Time frame: One day

Secondary Outcomes

Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking.

Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters

Time frame: One day

Study of differences in terms of activation of brain mapping

Study of differences in terms of activation of brain mapping between mechanical stimulation task arch simulating the place of the step (pace to 120 steps per minute) and a random mechanical stimulation (not reproducing the place of the pitch) . the secondary endpoint will be the analysis of spatiotemporal gait parameters

Time frame: One day

study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI.

study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI. the secondary endpoint will be the analysis of spatiotemporal gait parameters

Time frame: One day

Data from ClinicalTrials.gov

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