ATTUNE Single-Use Instrumentation vs. ATTUNE Reusable Instrumentation in Primary Total Knee Arthroplasty

Inclusion Criteria: 1. Subjects with severely painful and/or severely disabling Non-inflammatory Degenerative Joint Disease (NIDJD) resulting from osteoarthritis (OA) or post-traumatic arthritis. 2. Subject is male or female and between the ages of 22 and 80 years old, inclusive. 3. Subject requires a primary total knee replacement and is considered by the Investigator to be suitable for the specific knee prosthesis identified in the protocol. 4. Subject, who, in the opinion of the Investigator, is suitable for implantation using either RUI or SUI instrumentation. 5. Subject is able to speak and read English to facilitate comprehension of the Informed Consent Document. 6. Subject has given voluntary, written informed consent to participate in this clinical investigation and has authorized the transfer of his/her information to DePuy Synthes Joint Reconstruction. 7. Subject, in the opinion of the Investigator, is able to understand this clinical investigation and is willing and able to perform all study procedures and follow-up visits and co-operate with investigational procedures. Exclusion Criteria: 1. The Subject has, in the opinion of the Investigator, a severe deformity that will hinder achieving a mechanical axis alignment target of 0° ± 3°. 2. The Subject has, in the opinion of the Investigator, an existing condition that would compromise their participation and follow-up in this study. 3. The Subject has, in the opinion of the Investigator, a flexion deformity that will not allow for 0° extension postoperatively. 4. The Subject is a woman who is pregnant or lactating. 5. The Subject, in the opinion of the Investigator, is a drug or alcohol abuser (in the last 5 years) or has a psychological disorder that could affect follow-up care or treatment outcomes. 6. The Subject has participated in a clinical investigation with an investigational product in the last 3 months. 7. The Subject is currently involved in any personal injury litigation, medical-legal or worker's compensations claims. 8. The Subject has previous prosthetic knee replacement (any type including unicompartmental, total knee arthroplasty, patellofemoral arthroplasty or ipsilateral UTO/HTO) of the affected knee or a previous patellectomy. 9. The Subject presents with ankylosis of the hip joint on the side to be treated. 10. The Subject had a contralateral TKA and that knee was previously entered into the study. 11. The Subject requires simultaneous bilateral total knee replacements. 12. Any case in which Computer-Assisted Surgery (CAS) or TruMatch (or any other type of Custom Patient Instruments) is to be used, or any additional instrumentation are to be used for bone resections that are not provided as part of the ATTUNE RUI or SUI Instrument kits. 13. The Subject requires a device not specified in the protocol or the surgeon determines that the ATTUNE Knee System is not a suitable treatment.