Trial of Extended Release Bupivacaine for Pain Relief After Surgery

Inclusion Criteria: * Patients scheduled for elective outpatient laparoscopic cholecystectomy using a conventional 4-port laparoscopic procedure. * Must be able and willing to provide written informed consent, complete trial-related procedures, and communicate with the trial staff. * Males and females 18 years of age or older. * ASA Class I, II, or III. * Patients of child-bearing potential must agree to use a medically acceptable method of contraception to prevent pregnancy for the duration of their participation in the trial. * Must be living close enough to the investigative site to attend the four scheduled follow-up clinic visits. Exclusion Criteria: * Pregnant or nursing females. * Patients with absolute or relative contraindications to laparoscopic cholecystectomy. * Patients with prior midline abdominal surgery who are at risk for adhesions that may complicate laparoscopic cholecystectomy and/or accurate pain assessments. * Patients requiring emergency surgery or urgent surgery (fewer than 5 days between screening and surgery). * Patients with a pre-planned overnight stay or pre-planned hospital admission. * Patients scheduled for single incision, mini trocars, natural orifice transluminal endoscopic surgery (NOTES), robotic laparoscopic procedures, or any procedure (other than cholangiograms and minimal adhesiolysis) in addition to laparoscopic cholecystectomy. * Patients with known hypersensitivity to amide local anesthetics such as bupivacaine. * Patients with acute pain that is not due to cholecystitis. * Patients with a history of chronic pain unrelated to gallbladder disease. * Patients with ongoing depression or psychosis. * Patients undergoing long-term treatment with opioids or other analgesics, including acetaminophen, NSAIDs, anticonvulsants (gabapentin or pregabalin), and antidepressants (SSRIs, SNRIs, and tricyclics), but not including daily low-dose aspirin. * Patients who are being treated chronically with systemic corticosteroids or who will require peri-operative corticosteroids because of adrenal insufficiency (inhalational or topical corticosteroids are permitted). * Patients who may be unsuitable for opioid administration (such as sensitivity \[e.g., history of severe nausea and vomiting\] hypersensitivity, known history of abuse or addiction, or unwillingness to take prescribed rescue opioids). * Use of anticoagulants and antiplatelet drugs (with exception of low dose aspirin) in the 1 week prior to surgery. * Patients who are incapable of operating the electronic diary. * Patients participating in any other trial with an investigational drug or device concurrently or less than 30 days prior to surgery for this trial. * Patients who, in the Investigator's opinion, should not participate in the trial or may not be capable of following the trial procedures for any reason.