DDI (Effect of Metformin and Furosemide on Rosuvastatin PK)

Inclusion criteria: 1. Healthy male subjects according to the investigators assessment, based on a complete medical history including a physical examination, vital signs (BP, PR), 12-lead ECG, and clinical laboratory tests 2. Age of 18 to 55 years (incl.) 3. BMI of 18.5 to 29.9 kg/m2 (incl.) 4. Signed and dated written informed consent prior to admission to the study in accordance with GCP and local legislation Exclusion criteria: 1. Any finding in the medical examination (including BP, PR or ECG) is deviating from normal and judged as clinically relevant by the investigator 2. Repeated measurement of systolic blood pressure outside the range of 90 to 140 mmHg, diastolic blood pressure outside the range of 50 to 90 mmHg, or pulse rate outside the range of 45 to 90 bpm 3. Any laboratory value outside the reference range that the investigator considers to be of clinical relevance 4. Any evidence of a concomitant disease judged as clinically relevant by the investigator 5. Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders 6. Cholecystectomy and/or surgery of the gastrointestinal tract that could interfere with the pharmacokinetics of the trial medication (except appendectomy and simple hernia repair) 7. Diseases of the central nervous system (including but not limited to any kind of seizures or stroke), and other relevant neurological or psychiatric disorders 8. History of relevant orthostatic hypotension, fainting spells, or blackouts 9. Chronic or relevant acute infections 10. History of relevant allergy or hypersensitivity (including allergy to the trial medication or its excipients) 11. Intake of drugs with a long half-life (more than 24 h) within 30 days or less than 10 half-lives of the respective drug prior to administration of trial medication 12. Within 10 days prior to administration of trial medication, use of drugs that might reasonably influence the results of the trial 13. Participation in another trial where an investigational drug has been administered within 60 days prior to planned administration of trial medication 14. Smoker (more than 10 cigarettes or 3 cigars or 3 pipes per day) 15. Inability to refrain from smoking on specified trial days 16. Alcohol abuse (consumption of more than 30 g per day) 17. Drug abuse or positive drug screening 18. Blood donation of more than 100 mL within 30 days prior to administration of trial medication or intended donation during the trial 19. Intention to perform excessive physical activities within one week prior to administration of trial medication or during the trial 20. Inability to comply with dietary regimen of trial site 21. Subject is assessed as unsuitable for inclusion by the investigator, for instance, because considered not able to understand and comply with study requirements, or has a condition that would not allow safe participation in the study In addition, the following trial-specific exclusion criteria apply: 22. Myopathy 23. Hereditary galactose or fructose intolerance, lactase deficiency, or glucose-galactose malabsorption 24. Allergy or hypersensitivity against sulfonamides