Clinical Study of Concurrent Pazopanib and Radiotherapy for Non-metastatic Sarcoma Patients

Inclusion Criteria: * Histologically confirmed newly diagnosed intermediate to high grade soft tissue sarcoma localized to the extremities, trunk and chest wall or the head and neck area, for which the standard treatment is a combination of and radiotherapy and surgery(deep seated and/or \> 5cm according to the RECIST 1.1 criteria and/or an anticipated close resection margin and/or grade II/III according to the WHO definition) * Age ≥ 18 years * WHO performance status of ≤ 1 * Able and willing to undergo blood sampling for PK and PD analysis * Able to swallow and retain oral medication * Able and willing to undergo MRI scanning * Able and willing to undergo tumor biopsies * Adequate organ functions as described by the laboratory findings in the table 1. For thyroid function, the T4 and TSH values must be within normal values of the range of the participating centers * Written informed consent prior to performance of study-specific procedures or assessments and must be willing to comply with treatment and follow up. Exclusion Criteria * Prior malignancies; except another malignancy and disease-free for ≥ 5 years, or completely resected non-melanomatous skin carcinoma or successfully treated in situ carcinoma. * Patients with recurrent sarcomas (even without prior radiotherapy) * Ewing sarcoma and other PNET family tumors, rhabdomyosarcomas (both pediatric and adult), osteosarcomas * Clinically significant gastrointestinal abnormalities which might interfere with oral dosing diagnosed * Poorly controlled hypertension \[defined as systolic blood pressure (SBP) of ≥140 mmHg or diastolic blood pressure (DBP) of ≥ 90mmHg\] * Unstable or serious concurrent condition (e.g., active infection requiring systemic therapy) * Prolongation of corrected QT interval (QTc) \> 480 msecs on ECG * History of any of more of the following cardiovascular conditions within the past 6 months: * Cardiac angioplasty or stenting * Myocardial infarction * Unstable angina * Symptomatic peripheral vascular disease * Coronary artery by-pass graft surgery * Class II, III or IV congestive heart failure as defined by the New York Heart Association (NYHA) * History of cerebrovascular accident, pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6 months * Macroscopic hematuria * Hemoptysis that is clinically relevant within 4 weeks of first dose of pazopanib * Evidence of active bleeding or bleeding diathesis * Prior major surgery or trauma within 28 days prior to first dose of study medication and/or presence of any non-healing wound, fracture, or ulcer * Chemotherapy or radiation therapy within 2 weeks prior to the first dose of study medication * Biological therapy or treatment with an investigational agent within 28 days or five half-lives, whichever is longer prior to the first dose of study medication * Prohibited medications listed in the protocol for 14 days or five half-lives of a drug (whichever is longer) prior to visit 1 and for the duration of the study * Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib * Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial * Female patients who are pregnant, breast-feeding or male or female patients of reproductive potential who are not employing an effective method of birth control