To evaluate the natural history of visual function in subjects with IRD phenotypically diagnosed as Leber congenital amaurosis (LCA) or retinitis pigmentosa (RP) caused by RPE65 or LRAT gene mutations.
This is a retrospective, uncontrolled, multicenter, case history study to determine the natural history of visual function in patients with IRD phenotypically diagnosed as LCA or RP caused by autosomal recessive mutation in RPE65 or LRAT. Up to 60 subjects will be enrolled in this study at approximately 12 study centers in Canada, the US and Europe.
Study Type
OBSERVATIONAL
Enrollment
59
Wilmer Eye Institute - Johns Hopkins Hospital
Baltimore, Maryland, United States
Casey Eye Institute - Marquam Hill
Portland, Oregon, United States
The Hospital for Sick Children, Ophthalmology and Vision Sciences
Toronto, Ontario, Canada
Visual field
Time frame: Change in visual field over time. Previous assessments performed when subject was between the ages of 6 and 65 years
Visual acuity
Time frame: Change in visual acuity over time. Previous assessments performed when subject was between the ages of 6 and 65 years
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Montreal Children's Hospital, McGill University Health Centre
Montreal, Quebec, Canada
Glostrup Hospital and National Eye Clinic at the Kennedy Center
Glostrup Municipality, Copenhagen, Denmark
STZ Eyetrial at the Department of Ophthalmology - University of Tübingen
Tübingen, Germany
Rotterdam Ophthalmic Institute
Rotterdam, Netherlands
Jules Gonin Eye Hospital - Oculogenetic Unit
Lausanne, Switzerland
Moorfields Eye Hospital - Research and Treatment Centre
London, United Kingdom