The purpose of the study is to determine the effect of multiple doses of BMS-955176 on the QT interval corrected with Fridericia's method (QTcF) in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
315
The BMS-955176 dose in sentinel Cohort 1 will be 240 mg orally. The BMS-955176 dose in sentinel Cohort 2 will be determined based on the results of data from sentinel Cohort 1.
Subjects will be randomized to 1 of 12 sequences. Each sequence includes combination of different regimens (combination of BMS-955176, placebo and Moxifloxacin).
GSK Investigational Site
Austin, Texas, United States
Part 1: Reported adverse events
Time frame: Selected time points up to 24 hours postdose
Part 1: Vital sign measurements
Time frame: Selected time points up to 24 hours postdose
Part 1: Physical examinations
Time frame: Selected time points up to 24 hours postdose
Part 1: Safety 12-lead ECGs
Time frame: Selected time points up to 24 hours postdose
Part 2: ΔΔQTcF, the subject specific time-matched difference between the ΔQTcF (QT interval corrected with Fridericia's method) after administration of BMS-955176 and the ΔQTcF after administration of placebo
Time frame: Days 1 to 28
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