This study was part of a quality improvement project at the Department of Anesthesiology and Intensive Care Medicine, Charité - Universitaetsmedizin Berlin. Being in pain is reported to be one of the most important stressors in critically ill patients and worsens outcome. The evaluation of pain using validated scores in patients who are able to self-report significantly improves the quality of analgesic therapy and health related outcomes in intensive care patients. However, behavioral pain score that are used in sedated or delirious patients, often underestimate the severity of pain. The primary aim of this study is to investigate if measurement of the pupillary light reflex Amplitude correlates with the results of pain assessment using validated pain scores in critically ill patients.
Study Type
OBSERVATIONAL
Enrollment
80
Department of Anesthesiology and Intensive Care Medicine CVK/CCM, Charité - University Medicine
Berlin, State of Berlin, Germany
Correlation coefficient of pupillary light reflex amplitude and pain score
Pain is measured by Numeric Rating Scale - Visualised or Behavioural Pain Scale or Behavioral Pain Scale - Non Intubated and pupillary light reflex amplitude is measured by pupillometry
Time frame: Participants will be followed up to 6 days during their intensive care unit stay
Minimal pupil size [mm]
Time frame: Participants will be followed up to 6 days during their intensive care unit stay
Maximal pupil size [mm]
Time frame: Participants will be followed up to 6 days during their intensive care unit stay
Contraction speed of pupil [mm/s]
Time frame: Participants will be followed up to 6 days during their intensive care unit stay
Latency of pupil [ms]
Time frame: Participants will be followed up to 6 days during their intensive care unit stay
Pupillary light reflex [%]
Time frame: Participants will be followed up to 6 days during their intensive care unit stay
Richmond Agitation Sedation Scale (RASS)
Time frame: Participants will be followed up to 6 days during their intensive care unit stay
Glasgow Coma Scale (GCS)
Time frame: Participants will be followed up to 6 days during their intensive care unit stay
Delirium
Delirium is measured by the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
Time frame: Participants will be followed up to 6 days during their intensive care unit stay
Duration of mechanical ventilation (hours)
Time frame: Participants will be followed up during their intensive care unit stay, an average of 25 days
Intensive care unit length of stay (days)
Time frame: Participants will be followed up during their intensive care unit stay, an average of 25 days
Hospital length of stay (days)
Time frame: Participants will be followed up during their hospital length of stay, an average of 5 weeks
Hospital mortality (days)
Time frame: Participants will be followed up during their hospital length of stay, an average of 5 weeks
Discharge to home [%]
Time frame: Participants will be followed up during their hospital length of stay, an average of 5 weeks
Morbidity Scores
Time frame: Participants will be followed up during their intensive care unit stay, an average of 25 days
Amount of administered drugs
Time frame: Participants will be followed up to 6 days during their intensive care unit stay
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