Tumor Bed Hypofractionated IMRT After Surgery for Patients With Single,Large Brain Metastases From Solid Tumor

Istituto Clinico Humanitas87 enrolled

Overview

Investigators designed a study of a multimodality approach: surgery followed by hypofractionated intensity modulated radiation therapy (IMRT) using VMAT approach for patients with single, large brain metastases from solid primary tumor

Investigators designed a study to recruit patients with single, large brain metastases from solid primary tumor for a multimodality approach: surgery followed by hypofractionated intensity modulated radiation therapy (IMRT) using VMAT approach. The potential advantage of this treatment is to improve local control and to reduce toxicity compared with WBRT or SRS after surgical resection.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Brain Metastases

Interventions

brain metastatic patientsRADIATION

Surgery followed by hypofractionated intensity modulated radiation therapy (IMRT) using VMAT approach

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 years * Karnosky performance status (KPS) ≥70 * All Solid tumor (esclusion SCLC and Germinal tumors) * Controlled primary tumor * Controlled other metastatic site * Single metastatic lesion at diagnosis * Lesions ≥ 2.1 cm in maximum diameter (4 cm3), \< 3 cm conditioning mass effect or neurological deficits or massive aedema, unknown primary tumor * Estimated survival ≥ 3 months. * Written informed consent Exclusion Criteria: * Prior WBRT * KPS ≤ 70 * Other primary cancer * Pregnant women

Locations (1)

Istituto Clinico Humanitas

Rozzano, Milano, Italy

Outcomes

Primary Outcomes

Local control rate

Time frame: 6 months

Secondary Outcomes

Distant brain failure

Time frame: 6 months

Overall survival, statistical

Time frame: 6 months

Morbidity/mortality after surgery

Time frame: 1 month

Radionecrosis after treatments

Time frame: 6 months

Neuropsycological alterations after treatments, questionnaire

Time frame: 6 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.