Pupillometry Guided Remifentanil Administration and Total Opioid Consumption During Propofol - Remifentanil TCI

Pr Isabelle CONSTANT65 enrolled

Overview

The aim of this prospective randomized study was to evaluate the impact of peroperative pupillometry monitoring on per and post-operative opioid consumption in major gynecological surgery. All patients were anesthetized with TCI of propofol and remifentanil. In the intervention group, peroperative remifentanil target was guided by pupillometry. In the other group, remifentanil was administered according to standard practice.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Pain

Interventions

Videopupillometer AlgiscanDEVICE

pupillary diameter measurement every five minutes per-operatively

Standard practiceOTHER

remifentanil administration left to the discretion of the anesthesiologist in charge according to standard practice

PropofolDRUG

TCI

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I-II * Elective gynecological surgery * No ophtalmologic or neurologic disease * No chronic analgesic medication * Expected length of surgery 60 minutes minimum Exclusion Criteria: * ophtalmologic or neurologic disease * chronic analgesic medication

Locations (1)

Departement d'anesthesie Hopital Armand Trousseau

Paris, France

Outcomes

Primary Outcomes

peroperative remifentanil consumption in µg/kg/min

Time frame: duration of surgery

Secondary Outcomes

post-operative morphine requirements in mg/kg

includes initial morphine titration and subsequent PCA use

Time frame: 24 hours

peroperative propofol consumption in mg/kg/h

Time frame: duration of surgery

Data from ClinicalTrials.gov

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