Long-term Outcome of End-stage Renal Disease Patients Treated With Hig-efficiency Hemodiafiltration

Chulalongkorn University66 enrolled

Overview

A retrospective cohort study was conducted in 66 end-stage renal disease patients who underwent high-efficiency hemodiafiltration technique in King Chulalongkorn Memorial Hospital between 2001-2013 to determine the survival rate as well as other long-term outcome.

Growing evidences suggested the superiority of high-efficiency hemodiafiltration (HDF) which could provide both diffusion and convection in a single therapy compared with the conventional hemodialysis. However, the long-term, upto 10 years, outcome still limited. This retrospective cohort study was conducted in 66 end-stage renal disease patients who underwent high-efficiency hemodiafiltration technique in a single-center, King Chulalongkorn Memorial Hospital, between 2001-2013 to determine the survival rate as well as other long-term outcome

Study Type

OBSERVATIONAL

Enrollment

Conditions

End-stage Renal Disease

Interventions

HemodiafiltrationOTHER

Hemodiafiltration treatments were prescribed to the patients as their long-term renal replacement therapies

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18 years or more * Be diagnosed end-stage renal disease for more than one year * Have been regularly received long-term hemodiafiltration for more than 6 months. Exclusion Criteria: * Patients who received hemodiafiltration less than 6 months

Locations (1)

King Chulalongkorn Memorial Hospital

Pathumwan, Bangkok, Thailand

Outcomes

Primary Outcomes

Survival rate

The Kaplan-Meier survival curve and mean survival time will be demonstrated for primary outcome.

Time frame: 10 years

Secondary Outcomes

Comparison of survival differences between patients who start renal replacement therapy with HDF and who switched from hemodialysis as well as between diabetic and non-diabetic patient.

Survival differences between groups will be evaluated with the Kaplan-Meier method and compared using the log-rank test. The comparative groups include: * Patient who start renal replacement therapy with HDF (incident cases) vs. who switched from hemodialysis (prevalence cases) * Diabetic vs. Non-diabetic patients

Time frame: 10 years

Factors that associated with all-cause mortality

univariate and multivariate analysis the factors that might affected the long-term outcomes. The factors include dialytic parameters (spKt/Vurea, TAC urea), nutritional parameters (nPNA, albumin), inflammatory parameter (hsCRP), and biochemical parameters (BUN, Cr, Ca, Phosphate, iPTH, beta2-microglobulin, Hb, Ferritin, Transferrin saturation, Cholesterol, Triglyceride, HDL, and LDL)

Time frame: 10 years

Data from ClinicalTrials.gov

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