PDD vs PAD to Treat Initially Diagnosed MM

Inclusion Criteria: * Newly diagnosed and untreated multiple myeloma patients * Patients with age between 18 and 70 years * With a evaluable disease * ECOG score ≤2 * NE≥1.0×10E9 /L, Plt≥50×10E9 /L, Hb≥70 g/L * AST, ALT, ALP≤3×ULN, serum BIL≤ULN * LVEF≥ 50% * Not in pregnancy * Written informed consent are acquired Exclusion Criteria: * Severe heart failure (NYHA grade II or higher) * Active and uncontrolled severe infection * HIV positive * Have accepted any other anti-tumor drug within 30 days before the first dose of doxorubicin hydrochloride iposome or doxorubicin * Grade 2 or higher peripheral neuropathy before treatment * Have suffered any other malignancy in past 5 years * Females in lactation * Other situations that investigators consider as contra-indication for this study