Collagen Scaffolds Loaded With HUCMSCs for the Improvement of Erectile Function in Men With Diabetes

Inclusion Criteria: 1. type 1 or 2 diabetes,blood glucose controlled well, no effective with oral PDE-5i; 2. have a consistent partner who is willing to engage in sexual activity more than twice per month during the study; 3. males age 20-65 years; 4. IIEF-5 score is under 16; 5. penile arterial insufficiency or venous leakage (doppler): PSV \<25 cm/sec, or PSV \>25 cm/sec, EDV\>5cm/sec, RI\<0, 75; 6. HbA1c is between 6.5% 10%; 7. physical examination with no abnormalities; 8. who is willing to consent to participate in the study follow-up; 9. willing to limit alcohol intake eliminate use of recreational drugs for sexual encounters. Exclusion Criteria: 1. severe cardiovascular disease(angina, arrhythmia, cardiac failure, stroke), kidney failure, respiratory failure; history of malignancy; 2. positive for Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) syphilis test; 3. Testosterone level is less than 200ng/dl; 4. serum AST/ALT \>3\*upper limit of normal or creatinine \>1.5\*upper limit of normal; 5. HbA1c exhibit greater than 10%; 6. in the investigators judgment, with clinical significance of penis abnormalities, or has received penile prosthesis implantation surgery; 7. patients partner is trying to conceive during the trial period; 8. exposure to any investigational drug or procedure within 1 month prior to study entry or enrolled in a concurrent study that may confound results of this study; 9. unwilling and/or not able to give written informed consent.