Cardiac Function and Exercise Capacity in Pulmonary Arterial Hypertension

Centre Hospitalier Universitaire de Saint Etienne49 enrolled

Overview

Pulmonary Arterial Hypertension is characterized by a progressive increase in pulmonary vascular resistance inducing shortness of breath and exercise intolerance. We aim to correlate cardiac function (evaluated at rest by right heart catheterism and RMN) to exercise capacity (evaluated by endurance time at 75% of maximal workout), in prevalent patients with pulmonary arterial hypertension, and their evolution at three and twelve months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Pulmonary Arterial Hypertension

Interventions

RehabilitationBEHAVIORAL

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients * Patients with Pulmonary Arterial Hypertension (idiopathic, heritable or due to anorexigens), * Prevalent cases of pulmonary artery hypertension (≥ 6 months) confirmed by right heart catheterism, * Stable for at least 3 months, * Written consent. Exclusion Criteria: * Patients unable to proceed with six-minute walk test or CPET, or with contra-indication to exercise evaluation (syncope, low cardiac index, etc). * Exercise induced abnormality (evaluated during the initial CPET) precluding to further evaluation.

Locations (10)

CHU de Besançon

Besançon, France

CHU de Brest

Brest, France

CHU Gabriel Montpied

Clermont-Ferrand, France

Hôpital Sud de Grenoble

Échirolles, France

Outcomes

Primary Outcomes

Endurance time at 75% of the maximal workout (determinated during a cardiopulmonary exercise testing - CPET),

Time frame: 12 months after the inclusion