The purpose of this study : 1）to determine whether hydrocortisone is effective in the treatment of septic shock and 2) to identify the role of timing of low dose hydrocortisone administration in septic shock patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
118
Hydrocortisone was administered 200 mg/d as a continuous infusion for 6d, then tapered off. Once all vasopressors were discontinued, the taper protocol was initiated (half dose for three days, then quarter dose for three days and then stopped).
Vials containing normal saline as placebo were identical to those containing hydrocortisone. Placebo administration procedures were similar.
Northern Jiangsu Province people's hospital
Yangzhou, Jiangsu, China
28-day Mortality
Death from any cause at 28 days after the onset of septic shock
Time frame: 28 days
All Cause Mortality
Death from any cause at 90 days after the onset of septic shock
Time frame: 90 days
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