The Safety and Efficacy of Daclatasvir and Asunaprevir With Chronic HCV Genotype 1b Infection and Chronic Renal Failure

Inclusion Criteria: * HCV RNA Positive and Genotype 1b * No history or signs or symptoms of decompensated liver disease or hepatocellular carcinoma within 6 months * A patient who is on dialysis, or if not MDRD eGFR\<30ml/min * HCV treatment history: HCV treatment-naive participants, defined as never having received HCV treatment with any approved or investigational drug (including vaccines); OR HCV treatment-experienced, defined as having received previous HCV treatment with any (pegylated) interferon (\[Peg\]IFN)-based drug regimen (with or without ribavirin \[RBV\] and not including a direct-acting antiviral agent \[DAA\]). Last dose in this previous HCV treatment course should have occurred at least 2 months prior to screening * No baseline mutation NS5A polymorphism including L31F/I/M/V and Y93H Exclusion Criteria: * A patient who having received Daclatasvir or Asunaprevir * Pregnant women, women who are breastfeeding or who believe they may wish to become pregnant during the course of the study * Evidence of a medical condition contributing to chronic liver disease other than HCV or seropositive for HIV * Diagnosed or suspected hepatocellular carcinoma or other malignancies * Any history of, or current evidence of, clinical hepatic decompensation (e.g., ascites, encephalopathy or variceal hemorrhage) * Received solid organ or bone marrow transplant * Current alcohol or substance abuse judged by the investigator to potentially interfere with subject compliance * Significant renal, cardiovascular, pulmonary, or neurological disease and uncontrolled diabetes or hypertension in the opinion of the investigator * Known hypersensitivity to study drugs, metabolites, or formulation excipients * Who has taken investigational drugs within 2 months.