This cross-sectional monocentric study will describe transgender men transitioning into women and who had cosmetic silicone injection. The principal objective is to estimate the prevalence of Transgender with circulating monocytes containing silicone vacuoles in blood smears among Male to Female Transgender population with a history of cosmetic silicon injections. The secondary objectives are to describe the transgender population, to describe the quantity of silicone in vacuoles of circulating monocytes, and the association between dermatological complications (inflammatory and not inflammatory) and several clinical and biological characteristics (HIV status, level of immunosuppression, inflammatory syndrome, quantity of silicone which was injected , silicone quantity in blood smears).
Injectable liquid silicone is a permanent filling product which is no more used in France because of a high risk of complications. Cosmetic silicone injection is a common feminization approach for transgender populations. This cross-sectional monocentric study will describe transgender men transitioning into women and who had cosmetic silicone injection. The principal objective is to estimate the prevalence of Transgender with circulating monocytes containing silicone vacuoles in blood smears among Male to Female Transgender population with a history of cosmetic silicon injections. The secondary objectives are to describe the transgender population, to describe the quantity of silicone in vacuoles of circulating monocytes, and the association between dermatological complications (inflammatory and not inflammatory) and several clinical and biological characteristics (HIV status, level of immunosuppression, inflammatory syndrome, quantity of silicone which was injected , silicone quantity in blood smears).
Study Type
OBSERVATIONAL
Enrollment
66
Hôpitaux Universitaires Paris-Nord Val de Seine, site Bichat
Paris, France
The prevalence of Transgender with circulating monocytes containing silicone vacuoles in blood smear among Male to Female Transgender population, the day of their consultation.
The prevalence of Transgender with circulating monocytes containing silicone vacuoles will be calculated as the number of subjects with monocytes containing silicone vacuoles in blood smears on the number of subjects with a history of silicone cosmetic injection
Time frame: 1 day ,the day of their consultation
Number of monocytes with vacuoles of silicone in a standardized area of 25 monocytes per blood smear slide
Time frame: 1 day ,the day of their consultation
Size of silicone vacuoles in monocytes
Time frame: 1 day ,the day of their consultation
Inflammatory and not inflammatory dermatological complications
assessment of dermatological complications during the clinical examination
Time frame: 1 day ,the day of their consultation
Number of patients with a positive HIV status
Number of patients with a positive HIV status
Time frame: 1 day ,the day of their consultation
Level of immunosuppression estimated with viral charge
HIV viral load, the day of the admission or the last value known in the 6 month prior to the consultation
Time frame: 1 day ,the day of their consultation
Level of immunosuppression estimated with cluster of differentiation 4 cell (CD4) rate
CD4 cell count the day of the consultation or the last value known in the 6 month prior to the consultation. CD4 cell stands for Cluster of differentiation antigen 4 cell.
Time frame: 1 day ,the day of their consultation
Inflammatory syndrome estimated with C-reactive protein (CRP)
Time frame: 1 day ,the day of their consultation
Inflammatory syndrome estimated with ferritin
Time frame: 1 day ,the day of their consultation
Amount of injected silicone, in liters
Time frame: 1 day ,the day of their consultation
Time since the first silicone injection for cosmetic purposes, in years
Time frame: 1 day ,the day of their consultation
Comorbidities: Number of patients with history of Tuberculosis
Number of patients with history of Tuberculosis
Time frame: 1 day ,the day of their consultation
Comorbidities: Number of patients with history of Hepatitis B
Number of patients with history of Hepatitis B
Time frame: 1 day ,the day of their consultation
Comorbidities: Number of patients with history of Hepatitis C
Number of patients with history of Hepatitis C
Time frame: 1 day ,the day of their consultation
Comorbidities: Number of patients with history of Syphilis
Number of patients with history of Syphilis
Time frame: 1 day ,the day of their consultation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.