A random controlled trail to evaluate the efficacy of migraine standard electroacupuncture formula, and to analysis the regulation of the intensity-effects and to observe the peripheral NO, CGRP and NF-кB expression level of migraine patients after electroacupuncture treatment.
acupuncture group(group A): treated by acupuncture for 20 days, 1 time per day control group(group B): treated by FlunarizineHydrochloride for 20 days, 1 table per day.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
2
electro-acupuncture on acupoints according to the traditional syndrome diagnosis.once per day, for 20 days.
flunarizine hydrochloride ，10mg/day，for 20 days。
Longhua Hospital,Shanghai University of Traditional Chinese Medicine
Shanghai, China
Migraine Disability Assessment Questionnaire (MIDAS)
a scientifically reliable and valid measure of migraine disability that can improve communication between patients and physicians, assess migraine severity and act as an outcome measure to monitor treatment efficacy
Time frame: 20 days
The medical outcomes study 36-item short-form health survey(SF-36)
A 36-item short-form (SF-36) was constructed to survey health status in the Medical Outcomes Study
Time frame: 20 days
peripheral Nitrogen Monoxide(NO) protein expression
marker
Time frame: 20 days
peripheral Calcitonin gene related peptide(CGRP) protein expression
marker
Time frame: 20 days
peripheral Nuclear factor-kappa B(NF-кB) protein expression
marker
Time frame: 20 days
Visual Analogue Scale (VAS) to assess pain
Visual Analogue Scale (VAS) were applied to measure pain in patients
Time frame: 20 days
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