Study to evaluate the effect of lapatinib, a breast cancer resistance protein (BCRP) inhibitor, on the pharmacokinetics (PK) of JTZ-951 and to evaluate the safety and tolerability of JTZ-951 when administered alone and one hour after the administration of lapatinib.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
10
Unnamed facility
Minneapolis, Minnesota, United States
Cmax (maximum concentration)
Time frame: 10 days
tmax (time to reach maximum concentration)
Time frame: 10 days
AUC (area under the concentration-time curve)
Time frame: 10 days
t1/2 (elimination half-life)
Time frame: 10 days
Number of adverse events
Time frame: 10 days
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