Multi-Centre, Retrospective, Open Label Study, to Validate ML-PrediCare by Patients With Melanoma Under 1st and 2nd Lines of Immunotherapy

Inclusion Criteria: Patients who meet all of the following criteria are eligible for this study: 1. Gender: Female, Male. 2. Age: Eighteen years and older at the start of treatment. 3. Histologically confirmed unresectable Stage III or Stage IV melanoma, as per AJCC staging system. 4. Prior radiotherapy must have been completed at least 2 weeks prior to drug administration. 5. Measurable disease by CT, or PET-CT, or MRI per RECIST 1.1 6. Patient has at least one quantitative measurement of at least one target lesion (primary tumor or metastasis) before treatment. 7. Patient has at least one quantitative measurement of at least one target lesion (primary tumor or metastasis) during or after the treatment. 8. Patient has at least one recorded visit to the treating oncologist before treatment. 9. Patient has at least one recorded visit to the treating oncologist during or after the treatment. 10. Treatment as per SOC for melanoma. Exclusion Criteria: Patients meeting one or more of the following criteria are ineligible for this study: 1. History of another malignancy within the previous 2 years except for: • Adequately treated Stage I or II cancer currently in complete remission, or any other cancer that has been in complete remission for at least 2 years 2. Ocular melanoma 3. Active brain metastases or leptomeningeal metastases.