Effect of Omega-3 Fatty Acids on Oxidative Stress and Dyslipidemia in Pediatric Patients Undergoing Hemodialysis

Ain Shams University50 enrolled

Overview

The purpose of the study is to evaluate the effect of omega-3 fatty acids supplementation on pediatric patients undergoing hemodialysis via the measurement of the following before and after omega-3 administration:oxidative stress markers, inflammatory markers and serum lipids.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

End Stage Renal Disease

Interventions

omega-3DIETARY_SUPPLEMENT

dietary supplement

empty soft gelatin capsulesOTHER

empty softgels of matched size, shape and color

Eligibility

Sex: ALLMin age: 8 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients between 8 and 18 years old * Patients treated with HD for at least 6 months Exclusion Criteria: * Patients with malignancy and active inflammatory disease. * Patients who received vitamin E or any antioxidant treatment during the past 3 months.

Outcomes

Primary Outcomes

effect on oxidative stress status via measurement of superoxide dismutase and glutathione peroxidase and malondialdehyde

Time frame: four months

Secondary Outcomes

effect on serum lipid levels (HDL cholesterol, LDL cholesterol, total cholesterol, and triglycerides)

Time frame: four months

Data from ClinicalTrials.gov

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