Laser Speckle Flowgraphy in Caucasians: Age Dependence and Comparison With Doppler Optical Coherence Tomography

Inclusion Criteria: * Men and women aged over 18 years, nonsmokers * Subject is generally healthy with no current significant or a history of a significant neurological, cardiovascular, pulmonary (including asthma), hepatic, metabolic, rheumatic, autoimmune, hematological or renal disorder, as determined by the investigator's clinical judgment through collection of medical history and performance of a physical examination. A significant disorder is defined as a disease or medical condition associated with impaired health status, requiring regular or current medical treatment and/or follow up. For the purposes of this study, an investigator may classify a medical condition as a nonsignificant disorder despite the fact that the subject receives treatment. Subjects having controlled Stage 1 hypertension (blood pressure of 140-159 mmHg systolic and/or 90- 99 mmHg diastolic) are eligible for participation in this study. * Normal ophthalmic findings, ametropia \< 6 Dpt Exclusion Criteria: * Symptoms of a clinically relevant illness in the 3 weeks before the first study day * Wearing of contact lenses * Ocular infection or clinically significant inflammation * Ocular surgery in the 3 months preceding the study * Blood donation in the 3 weeks preceding the study * Pregnancy, planned pregnancy or lactating * Opacities of the cornea (e.g. corneal scars, corneal oedema), the lens (e.g. Lens opacities classification system version II (LOCS-II) grading \> 2, posterior capsule opacification) or the vitreous (e.g. vitreous haemorrhage, asteroid hyalosis)