The aim of this study is to assess the efficacy in PTSD treatment of concomitant voluntary reactivation of personal traumatic memories with neuromodulation of the right dorsolateral prefrontal cortex using 10Hz rTMS, compared to 1Hz rTMS, during 2 weeks.
Post-Traumatic Stress Disorder (PTSD) is characterized by intrusive and persistent memory of past result from an event causing or able to cause death, be a threat of death, a severe injury or constitute a threat for physical integrity. It is a frequent disorder in general population (8%). In France, The most frequent traumatic events causing PTSD are serious accidents, rape, physical assaults, violence, etc. PTSD treatment involves antidepressant and cognitive and behavioural psychotherapy, which encourage exposure to elements that remind the trauma (memories, circumstances), with the objective of reducing the fear associated with the traumatic memories. Innovative therapeutic strategies aim to improve the psychotherapeutic effect with enhancement drugs or using neuromodulatory techniques, such as repeated transcranial magnetic stimulation (rTMS). The aim of this study is to assess the efficacy in PTSD treatment of concomitant voluntary reactivation of personal traumatic memories with neuromodulation of the right dorsolateral prefrontal cortex using 10Hz rTMS, compared to 1Hz rTMS, during 2 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
39
trauma exposure + repeated transcranial magnetic stimulation at 1Hz
trauma exposure + repeated transcranial magnetic stimulation at 10Hz
psychoneurological assessment
Change from baseline Score at Clinician administered PTSD scale
Score at Clinician administered PTSD scale
Time frame: inclusion ; 1 months; 3 months
Change from baseline Score at PTSD Checklist (self-assessment)
Score at PTSD Checklist (self-assessment) for severity of PTSD
Time frame: inclusion ; 1 month; 3 months
Change from baseline Score at PTSD Checklist (self-assessment) for different dimensions of PTSD
Score at PTSD Checklist (self-assessment) for severity of different dimensions of PTSD
Time frame: inclusion ; 1 month; 3 months
Change from baseline Score at anxiety and depression item on Hamilton Anxiety Rating Scale (HAM-A)
Score at anxiety and depression item on Hamilton Anxiety Rating Scale (HAM-A)
Time frame: inclusion ; 1 month; 3 months
Change from baseline Score at depression item on Hamilton Anxiety Rating Scale (HAM-A)
Score at depression item on Hamilton Depression Rating Scale (HAM-D)
Time frame: inclusion ; 1 month; 3 months
Change from baseline heart rate
heart rate
Time frame: inclusion ; 1day ; 1 month, 3 months
Change from baseline electrodermal conductance
electrodermal conductance measure
Time frame: inclusion ; 1day ; 1 month, 3 months
Adverse effect
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electrodermal conductance measure
heart rate measure
Adverse effect
Time frame: inclusion ; 1day ; 1 month, 3 months