This study evaluates physical performance in cancer outpatients during a multimodal therapy. Half of the patients will receive physical exercise und nutrition program in combination with a specially formulated whey protein supplement, while the other half will receive standard care.
The time period of Intervention will last 3 month, measurements will be conducted at baseline and 3 month. After 6 month there will be an additional follow-up test point to assess the sustainability of the intervention. The 3-month intervention study consists of a physical exercise program and nutrition counseling in combination with a specially formulated whey protein supplement high in leucine. The standardized training program will be performed twice a week in the physical department of the Kantonsspital Winterthur (KSW) and once a week in a home based setting. Additionally, participants of the intervention group will be aks to consume 15 g of the nutrient supplement powder with approximately 150 ml water. On workout days the supplement should be taken twice a day and on the remaining days once a day. During the three month intervention study participants will take part in a nutrition counseling for at least three times.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
52
The standardized Training program will be performed twice a week in the Kantonsspital Winterthur and once a week in a home based setting
At least 3 times, participants will receive nutrition counseling to improve energy- and protein intake
On workout days study participants will consume twice a day 15 g of the supplement powder with approximately 150 ml water. On the remaining days participants consume the supplement once a day.
Kantonsspital Winterthur
Winterthur, Switzerland
Change in physical performance
Physical performance will be assessed with the short physical performance battery
Time frame: measured at week 0, 12 and 24
Change in body composition
Body composition will be assessed with bioimpedance
Time frame: measured at week 0, 12 and 24
Change in quality of life
Quality of life will be assessed with the questerionnaire EORTC-QLQ-C30
Time frame: measured at week 0, 12 and 24
Change in fatigue
Fatigue will be assessed with the questionnaire brief fatigue inventory
Time frame: measured at week 0, 12 and 24
Change in physical function
Physical function will be assessed with 60s-sit-to-stand-test and timed-up\&go-test
Time frame: measured at week 0, 12 and 24
Change in nutritional status
Nutritional status will be assessed with hand grip, nutritional risk screening 2002 and patient-generated subjective global assessment
Time frame: measured at week 0, 12 and 24
Change in diet history
3-day food records brought in at weeks 0, 12 and 24 will be analyzed for energy- and protein intakes
Time frame: measured at week 0, 12 and 24
Number of re-hospitalization
Number of re-hospitalization
Time frame: up to 24 weeks
Change in WHO performance status
Change in WHO performance status
Time frame: measured at week 0, 12 and 24
Overall survival
Overall survival
Time frame: up to 24 weeks
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