Cluster Headache and SPINK-1 Gene

Assistance Publique Hopitaux De Marseille42 enrolled

Overview

Cluster headache (CH) is a rare, excruciating primary headache disorder. A genetic basis has been suggested by family and twin studies, but the mode of transmission seems to vary and the amount of heritability is unclear. The number of genetic association studies investigating variants implicated in the pathophysiology of CH is limited. The HCRTR2 1246G \> A and the ADH4 925A \> G polymorphisms have been associated with CH. The former has been confirmed and may affect the hypothalamic hypocretin system. The aim of the present study was to investigate the possible link between SPINK 1 gene and cluster headache.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Episodic or Chronic Cluster Headache

Interventions

blood sampleGENETIC

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * People aged 18 or over * Patient consulting in Marseille's or Nice's Pain departments * Patient agreeing to participate to the research study * Patient with health insurance Exclusion Criteria: * People aged under 18 * Patient refusing to participate to the research study * Patient with deprivation of liberty

Locations (1)

APHM

Marseille, France

Outcomes

Primary Outcomes

SPINK1 genotyping

Time frame: 2 months

Data from ClinicalTrials.gov

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