The Effect of Gemcabene on Insulin Sensitivity in Nondiabetic Subjects

Inclusion Criteria: * Good health, as determined by medical history, physical examination, EKG and clinical laboratory assessments * Males; and females of non-reproductive potential * Obesity * Non-diabetic Exclusion Criteria: * Use of any medication considered unacceptable by the clinical investigators during the 14-day period before the start of Day 1. Hormone Replacement Therapy is acceptable. * Use of a lipid-lowering agent (niacin, fibrates, statin) during the 8 weeks before screening * Use of any anti-diabetic medications * Use of any steroid medications * Donation of any blood or plasma product or participation in another study in the 30 days prior to Day 1 * If female, pregnant, lactating or of childbearing potential; and * History of significant reaction to any fibrate lipid-lowering agent