The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis

Hui Bu200 enrolled

Overview

The study aimed to evaluate the relationships between the gene polymorphisms of leukotriene A4 hydrolase(LTA4H) and Dexamethasone treatment for tuberculous meningitis in Chinese patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

200

Conditions

Tuberculous Meningitis

Interventions

Dexamethasone acetateDRUG

Eligibility

Sex: ALLMin age: 14 Years

Medical Language ↔ Plain English

Inclusion Criteria: patients were eligible to enter the study if they met the diagnositic criteria for possible, probable or definite Tuberculosis meningitis(TBM). Exclusion Criteria: Patients were excluded if they were infected with HIV, diagnosed as carcinomatous meningitis, viral meningitis, purulent meningitis, cryptococcus meningitis.

Outcomes

Primary Outcomes

MRI

whether MRI show infarction, hydrocephalus, meningeal enhancement

Time frame: 6 month

changes of cerebrospinal fluid

Time frame: 1 year

changes of clinical symptoms

headache duration, duration of fever,presence of cranial nerve damage

Time frame: 1 year

Data from ClinicalTrials.gov

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