Comparison Between High-density Electroencephalography and Conventional Electroencephalography for Comatose Patients

Centre Hospitalier Universitaire de Besancon50 enrolled

Overview

The purpose of this study is to measure whether high-density electroencephalography can improve the detection of electrophysiological signs of awareness compared to conventional electroencephalography in post-anoxic comatose patients

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Post Anoxic Coma

Interventions

high-density electroencephalographyDEVICE

Auditory stimulations during electroencephalography recording

Conventional electroencephalographyDEVICE

Auditory stimulations during electroencephalography recording

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * post anoxic coma * over 18 years old * agreement from families * alive 4 days after the beginning of coma Exclusion Criteria: * traumatic coma * non-traumatic but not anoxic coma * patients with severe comorbidity previous to coma * refusal of families to participate to the study * contraindication to a high-density electroencephalography exam

Locations (1)

CHRU Besançon

Besançon, Franche-Comte, France

Outcomes

Primary Outcomes

Number of patients who recovered and who presented a mismatch negativity in high-density but not conventional electroencephalography

mismatch negativity is an electrophysiological response recorded after the presentation of deviant auditory stimulations Recovery is assessed 1 month after the beginning of coma

Time frame: 4 days after the beginning of coma

Secondary Outcomes

Number of patients who recovered and who presented a mismatch negativity in high-density but not conventional electroencephalography

Time frame: 7 days after the beginning of coma

Number of patients who recovered and who presented a mismatch negativity in high-density but not conventional electroencephalography

Time frame: 19 days after the beginning of coma

Data from ClinicalTrials.gov

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