Effects of Terlipressin on Blood Loss and Transfusion Requirements During Major Liver Resection.

Assiut University84 enrolled

Overview

To evaluate the effects of Terlipressin infusion on blood loss \& transfusion requirements in cirrhotic patients undergoing major liver resections.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Hepatectomy, Surgical Blood Loss, Terlipressin

Interventions

TerlipressinDRUG

Terlipressin will be given as an intravenous injection of 2μg/kg/h to be continued throughout the surgery and weaned off over four hours postoperatively.

normal salineDRUG

Same volumes of normal saline infusion, throughout the operation then gradually withdrawn over 4 hours.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients older than 18 years of age, American Society of Anesthesiology (ASA) classification class I and II and assigned for elective resection of 2 or more liver segments portal hypertension Exclusion Criteria: * Patients with Child-Turcotte-Pugh grade B or C, clinically significant portal hypertension (splenomegaly, thrombocytopenia with platelets \< 1011/L, esophageal varices grade 2 or more), Preoperative renal failure (GFR \< 50ml/min), heart failure, Bradyarrhythmia (heart rate \< 60/min), history of hemorrhagic stroke, Uncontrolled arterial hypertension (Blood pressure \>160/100mmHg), and Pregnancy

Locations (1)

Assiut University hospital

Asyut, Asyut Governorate, Egypt

Outcomes

Primary Outcomes

blood loss

blood loss in ml

Time frame: intraoperative period

Secondary Outcomes

blood units transfused

number of packed RBCs units transfused

Time frame: intraoperative period

lactate level

lactate level in blood gas sample in mmol/L

Time frame: at start and end of resection

Data from ClinicalTrials.gov

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