Analytical Treatment Interruption in HIV Positive Patients

Inclusion Criteria: * Able and willing to provide written informed consent * Men and women age ≥ 18 and \< 65 years. * Confirmed HIV-1 infection at any time prior to study entry. * Infected with HIV-1 subtype A, B, C, D, CRF01\_AE or CRF02\_AG virus * Participant should take ART for at least 2 years before baseline with no changes in the ART regimen for at least 90 days prior to study entry. ART regimen is defined as mono- or bi-therapy or a combination of three or more active antiretroviral drugs * CD4 T-cell count is \>= 500/μl for a period of at least 3 months prior study entry * Nadir CD4+ T-cell count is ≥300/μl. A lower nadir CD4+ T-cell count will be allowed if measured at time of acute infection as far as the relative CD4+ count remains above 20%. An acute infection is defined as an association of a clinical picture of retroviral syndrome together with a seroconversion in HIV serology or an incomplete confirmation test. * Plasma viral load \< 50 copies/ml for at least 2 years before baseline. (Occasional "blips" will be permitted if it happened more than six months before study entry. An occasional blip is defined as an intermittent viremic episode with a viral load above detection level but below 200 copies/ml and a return to an undetectable level in a next control). * Willingness to complete scheduled assessments and participant visits. * Adequate peripheral vein access to perform leukapheresis * All female participants of childbearing potential should have a negative pregnancy test. These women and their partner should use double barrier contraception during the study. Females of reproductive potential will need a negative serum or urine pregnancy test at screening. They are defined as those who have not reached menopause or been post-menopausal for at least 24 consecutive months, who have had menses within the preceding 24 months, or women who have not undergone surgical sterilization, specifically hysterectomy, or bilateral oophorectomy or tubal ligation) . NOTE: Acceptable documentation of hysterectomy and bilateral oophorectomy, bilateral salpingectomy, tubal micro-inserts, partner who has undergone vasectomy, and menopause is participant-reported history. All participants must agree not to participate in a conception process (e.g., active attempt to become pregnant, sperm donation, or in vitro fertilization). Exclusion Criteria: * Previous or current history of AIDS defining event as defined in category C of the 'Centers for disease control and prevention (CDC)' clinical classification . * Any acute infection or serious medical illness within 60 days prior to study entry. Participants will be excluded from this study for a serious illness (requiring systemic treatment and/or admission) until the subject either completes therapy or is clinically stable on therapy, in the opinion of the Investigator, for at least 14 days prior to study entry * History of resistance to antiretroviral drugs, documented by genotyping. * Active hepatitis B or C virus infection: as defined with a positive serology for either disease with signs of active viral replication? * Significant risk of HIV transmission during treatment interruption in the opinion of the investigator. This includes evidence for unsafe sexual contacts. * Current or past history of cardiomyopathy or significant ischemic or cerebrovascular disease. * History of HIV-related thrombocytopenia. * Active renal disease (defined as a glomerular filtration rate (calculated by MDRD equation) below 50 ml/min or the presence of HIV associated nephropathy in the past medical history. * Current or known history of cancer (with the exception of in situ cervix carcinoma or squamous cell carcinoma of the skin) within five years prior to screening. * Pregnancy and breastfeeding. * Any condition, including psychiatric and psychological disorders that might interfere with adherence to study requirements or safety of the participant. * Prior use of any HIV vaccine and/or non-established experimental therapy * Any of the following laboratory test results at screening: 1. Confirmed hemoglobin \<11g/dl for women and \<12 g//dl for men 2. Confirmed platelet count \< 90,000/μl 3. Confirmed neutrophil count \<1200/μl 4. Confirmed AST and/or ALT \> 5 x upper limit on normal range (ULN). One retest within 14 days is allowed. * Receipt of any immune modulator or suppressor within 30 days prior study entry, including, but not limited to drugs such as corticosteroids (with the exception of corticosteroids used for topical use), granulocyte-macrophage colony-stimulating factor, interleukin (IL)-2, IL-7 and IL-15. * Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements. * Participation in other interventional studies involving investigational drug.